Before anyone starts panicking, I just have a few words about this vague description.
I found this little piece of information interesting, that their last episode will be a Weeping Angels episode. Now everyone is imagining the worst case scenario, but I don't think Moffat will purposefully kill off Amy and Rory in such a brutal way. It will be devastating seeing them depart from the Doctor, especially since they've become family to him in more ways than one and we've all grown attached to their little family unit over the last two series. But I've thought about what this could mean. Knowing that this episode will be heartbreaking, and knowing that they will be encountering the Weeping Angels, I'm thinking that the angels do end up getting to Amy and Rory but instead of what happened in "The Time of Angels"/"Flesh and Stone" we return to what the Weeping Angels normally do, misplacing them somewhere else in time.
This actually coincides with my previous theory of the Doctor being too late for them, just in a different way.
I think some people are forgetting that Moffat has introduced the entire "just this once, everybody lives" aspect of the show. He wrote the episode "Blink" which first introduced the Weeping Angels, where the angels kill you by misplacing you in time but that doesn't mean you still can't live a long, healthy and happy life elsewhere. He also wrote "Forest of the Dead" where the Doctor saves River Song's consciousness. I have no doubt he'll give the same kind of ending for the Ponds, tragically beautiful and done with dignity and true to their characters.
Again, this is just my own personal speculation. Whatever happens it will rip out our hearts either way. ;__;
In short, I am so not ready but remaining optimistic nonetheless.
Unrelated, but second season of Game of Thrones premieres tonight. I suspect the Internets will be broken by the time it does, flooded with much flailing, more than there already is. I can't wait.